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BayesHammer: Bayesian Clustering for Error Correction in Single-Cell Sequencing

Sergey I. Nikolenko, Anton I. Korobeynikov, Max A. Alekseyev
BMC Genomics 2013, 14(Suppl 1):S7


Error correction for sequenced reads remains difficult, especially for single-cell sequencing projects with extremely non-uniform coverage. We present the BayesHammer error correction tool that uses Bayesian subclustering to correct sequencing reads. While BayesHammer was designed for single-cell sequencing, we demonstrate that it also improves on state-of-the-art error correction tools for standard (multi-cell) sequencing data.